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Study confirmed that HIV can cross from chimps to humans

Staff Writer | July 23, 2016
In the early 1900s, probably near a West African rainforest, it's thought that a hunter or vendor of bush meat acquired the first strain of a simian immunodeficiency virus that virologists consider the ancestor of HIV.
Spreading virus   Probably near a West African rainforest...
A new study led by the University of Nebraska-Lincoln has supported this hypothesis by reporting the first in vivo evidence that strains of chimpanzee-carried SIVs can infect human cells. They include the SIV ancestor of HIV-1 M - the strain responsible for the global HIV pandemic - and another ancestral strain of HIV found only among residents of Cameroon.

Yet the researchers further discovered that the SIV ancestors of two HIV strains not identified in humans also managed to invade human cells after multiple exposures in the lab.

"The question was whether SIV strains that have not been found in humans have the potential to cause another HIV-like infection," said senior author Qingsheng Li, associate professor of biological sciences and member of the Nebraska Center for Virology. "The answer is that, actually, they do. They get replicated at a very high level. It's surprising."

Li and his colleagues came to the conclusions after inoculating mice that were implanted with human tissues and stem cells, which stimulated the growth of other cells essential to the human immune system.

To explore why humans have acquired certain HIV strains while avoiding others, the team injected low doses of the four SIV strains into separate groups of the mice.

The authors found that the inferred SIV forerunners of HIV-1 M and the Cameroon-specific strain required fewer opportunities to infect the mice than did the two SIV strains whose HIV descendants have not been found in humans.

According to Li, this may stem from the fact that the genetic makeup of the latter two strains differs more from HIV-1 M than does the Cameroon strain, which shares more genes with its pandemic cousin.

"Based on our experiments, we clearly see some differences between the strains," said Li, whose team collaborated with the Frederick National Laboratory for Cancer Research. "That implies that there might be differences in the likelihood of cross-species transmission when a person is exposed to one strain versus another."

The team also found evidence for the long-suspected notion that SIV strains mutate upon entering cells to overcome human-specific barriers to infection. Within 14 weeks, the same viral gene in two different SIV strains - including the ancestor of HIV-1 M - regularly underwent mutations at two key positions on that gene.

Li and lead author Zhe Yuan, a doctoral student in biological sciences, said the recent outbreak of the Zika virus - which remained relatively quiet for decades following its 1947 discovery in a monkey - underscores the value of pre-emptively identifying viruses that can jump from animals to humans.